Pharmacological characterization of endothelin-induced contraction in the guinea-pig oesophageal muscularis mucosae
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چکیده
منابع مشابه
Unique properties of muscularis mucosae smooth muscle in guinea pig urinary bladder.
The muscularis mucosae, a type of smooth muscle located between the urothelium and the urinary bladder detrusor, has been described, although its properties and role in bladder function have not been characterized. Here, using mucosal tissue strips isolated from guinea pig urinary bladders, we identified spontaneous phasic contractions (SPCs) that appear to originate in the muscularis mucosae. ...
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We have compared the reactivity to spasmogens of longitudinal muscularis mucosae isolated from the human, guinea pig and rat colon in vitro. The muscularis mucosae isolated from the human distal colon responded with a sustained contractions to carbachol (10 nM-30 microM), in a concentration-dependent manner, and the maximum contraction was comparable to that with high potassium concentration (1...
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In the present study, endothelin (ET) agonists and receptor selective antagonists were used to characterize ET receptors mediating constriction in guinea pig mesenteric veins (250-300 micrometers diameter) in vitro. The contribution of ET-evoked vasodilator release to venous tone was also explored. Computer-assisted video microscopy was used to monitor vein diameter. Endothelin-1 (ET-1), endoth...
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ژورنال
عنوان ژورنال: British Journal of Pharmacology
سال: 1998
ISSN: 0007-1188,1476-5381
DOI: 10.1038/sj.bjp.0702140